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Derksen,
H.E. 1965. Axon membrane
voltage fluctuations.
Acta Physiol. Pharmacol., Neerlandica 13: 373-466
PhD-thesis: November 10th, 1965
Report
on the actual discovery of membrane noise.
This
work is the result of our cooperation:
Derksen developed the
symmetrical recording and amplifier system, of which the sensitivity
had to be increased from the mV range into the µV range. It was symmetrical in order to use
cross-correlation to obtain the common noise source of the
axon membrane, enabling the calculation of its power spectrum.
My contribution consisted of the preparation of each individual
nerve fiber and the cooperative development of the nerve chamber used
for the measurements.
All experiments were performed by both of us
together.
This
paper was, therefore, the result of joint work. A
single-author publication was, however, necessary since with respect
to working for a thesis teamwork
was at that time still
unacceptable to the University of Leiden.
To cover this problematical situation we planned the Science publication to appear in 1965. It was delayed, however,
because the phenomenon
of membrane noise discovered by us was still considered being
an
artifact generated by
instrumental noise (as happened before with my results on excitability
fluctuations). So it appeared in 1966.
The 1977 article in Nature covered
the
other part of the work discussed in this thesis.
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Derksen, H.E. and A.A.
Verveen, 1966. Fluctuations of resting neural membrane potential. Science 151: 1388-1389.
Our
formal report
on the actual discovery of membrane noise.
Received
by the editorial board on October 25th, 1965, this paper appeared in print on
March 18th, 1966.
This article was instrumental for our peers to
accept the existence of membrane noise and, together with the following
two papers, to accept the stochastic nature of neuronal activity.
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Verveen,
A.A., H.E. Derksen and K.L.
Schick, 1967. Voltage fluctuations of neural membrane. Nature, 216: 588-589.
With
this
publication, we tried to attract the attention of our peers to the
phenomenon that membrane voltage noise is stochastic. The
nature and the amount of variability depends upon membrane
voltage level.
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152
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Verveen, A.A., en H.E. Derksen,
1968. Fluctuation phenomena in nerve membrane.
Proc. IEEE
56:
906-916.
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772
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Verveen, A.A., 1969.
An introduction to the use of time series analysis in physiology.
In: W. Reichardt, ed. Processing
of optical data by organisms and by machines.
Proceedings of the International School of Physics “Enrico
Fermi”, Course 18. Academic Press, New York London: 291-327.
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Verveen, A.A. and
H.E. Derksen, 1969. Amplitude distribution of axon membrane noise
voltage.
Acta
Physiol. Pharmacol. Neerl. 15: 353-379.
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Siebenga,
E. and A.A. Verveen, 1971. The dependence of the 1/f noise
intensity of the node of Ranvier on membrane potential.
Proceedings First European Biophysics Congress: 219-223.
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Siebenga,
E. and A.A.
Verveen, 1972. Membrane noise and ion transport in the node of Ranvier.
In: Biomembranes
vol. 3:
Passive Permeability of Cell Membranes,
F. Kreuzer and J.F.G. Slegers,
eds, Plenum Press, NY – London: 293-298.
Analysis
of components of the noise power spectrum.
The shot
component, predicted
by Chuck
Stevens was discovered to exist
both by Siebenga et al. and Harvey M. Fishman, 1972
(Excess noise
from small patches of squid axon membrane.Biophys. Soc. Abstr.
119a) .
Footprint
Since
2000
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310
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Siebenga, E., A.W.A.
Meyer and A.A. Verveen, 1973. Membrane shot-noise
in
electrically depolarized nodes of Ranvier.
Pflügers Arch. 341: 87-96.
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Verveen, A.A., 1973.
Electric membrane noise and channel dynamics.
In: Regulation and
Control in Physiological Systems.
A.S. Iberall and A.C.
Guyton, Eds. Pittsburg, PA., Instrument Society of America; 81-84.
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Verveen, A.A. and L.J. DeFelice,
1974. Membrane Noise.
Progr.
Biophys. Mol. Biol. 28:
189-265.
Review paper by invitation.
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Siebenga, E., J.
de
Goede, A.A. Verveen, 1974.
The influence of TTX, DNP and TEA on membrane flicker noise and shot
effect noise of the frog node of Ranvier.
Pflügers
Arch. 351:
25-34.
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Schick, K. L, and A.A.
Verveen, 1974. 1/f noise with a low frequency white noise limit.
Nature
251:
599-601.
Investigation of the power spectrum of particle
flow through the
elongated stem of an
hourglass.
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Verveen, A.A., 1974. Random
processes in the nervous system.
Methodology
and Science 7:
80-91.
In
this paper, I discuss possible functions of noise and other sources of randomness
in the nervous system.
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Van
den Berg, R.J., J. de Goede
and A.A. Verveen, 1975. Conductance Fluctuations in Ranvier
Nodes.
Pflügers
Arch. 360:
17-23.
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Moolenaar,
W.H., de Goede, J.
and A.A. Verveen, 1976. Membrane Noise in Paramecium.
Nature
260,
344-346.
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De Goede, J.
and A.A. Verveen, 1977. Electrical membrane noise: its origin
and interpretation.
In: Electrical
Phenomena at the Biological Membrane Level.
E. Roux, ed.
Proc. 29th Int. Meeting Soc. Chimie Physique, Orsay, 12-15 October
1976.
Elsevier, Amsterdam: 337-348.
Footprint
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Van den Berg, R.J.,
E. Siebenga, J. de Goede, W.H. Moolenaar and A.A. Verveen, 1977.1/f
noise in nerve membranes.
In: Fyokyo, H., et al., eds. Proceedings
of the Symposium on 1/f Fluctuations,
The Institute of
Electrical Engineers of Japan, Tokyo, July: 97-105.
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De Goede, J., M.W.
Vonk, R.J. van den Berg, H. van Rijn and A.A.
Verveen, 1977.
Some
problems in membrane noise research.
Ann. N.Y.
Acad. Sc.
303:
389-398.
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