|Appraisal of the papers by our peers
||Waardering van the artikelen
on fluctuations and noise
|A. Toevalsprocessen in het zenuwstelsel (Engels)
"The application of fluctuation analysis to conduction processes
in excitable membranes has developed
since the early
work of Derksen and Verveen* (1966) on the node of Ranvier."
Membrane Ionic Currents, Current Noise, and. Admittance in Isolated
Yves Pichon, Denis
Poussart, and Graham V. Lees, 1983
Chapter 10 in: Chang, D.C., Tasaki, I., Adelman, W. J., and
Function in Excitable Cells, H. R., Eds. Springer
"In 1966, Verveen and Derksen* published an
intriguing investigation of
membrane noise aimed at understanding the probabilistic behavior of
neurons in the CNS.
By describing a potential role for noise in computation,
this pioneering work changed the prevalent view in biology of
noise as a bothersome phenomenon."
S.F. & F. Jaramillo. 1998
Getting the most out of noise in the central nervous system
Trends in Neurosciences, 21 (4): 137-145
"In fact, it is widely recognized that
Derksen and Verveen* changed the
prevalent view of noise from a bothersome phenomenon to
an essential component in biological
Roy, S & R. Llinás. 2011
The role of noise in brain function
* Derksen, H.E. and A.A.
Fluctuations of resting neural membrane potential.
Science 151: 1388-1389.
More info on this paper
been well known that stochastic phenomena influence action potential
since Verveen’s extensive descriptions of spike timing and threshold
J.T. Rubinstein, J.A White. 2002
(pdf, 170 kB)
Comparison of algorithms for the simulation of action potentials with
stochastic sodium channels
Annals of Biomedical Engineering, 30 (4): 578-587
This paper refers to the role played by my Ph.D. thesis:
Verveen, A.A. 1961. Fluctuation in excitability.
on my thesis
J.T. 1995 (pdf, 1.166 kB)
Threshold fluctuations in an N sodium channel model of the node of Ranvier
Biophysical Journal 68: 779-785
Contains an extensive discussion of our noise work done
during the 6th and 7th decade of the former century
A potential application in medicine:
I.C. , M.W. White, L.S. Irlicht, S.J. O'Leary, G.M. Clark. 1999
The effects of stochastic neural activity in a model predicting intensity
with cochlear implants: low-rate stimulation
IEEE Transactions on Biomedical Engineering, 46(12)
It is a great pity
that my colleague and co-worker Hans Edi Derksen died already a long time ago.
Thus, he never learned that our views on the roles of noise and chance processes
in biological systems generated a paradigm shift, are now accepted by the scientific community.
"The behaviour cycle of the Boa constrictor in captivity
|The number of researchers working on the topics I am interested in is rather small. See for instance the number of articles using the work of me and my co-workers. Does the horror incerto play a role?
||Het aantal onderzoekers dat in de gebieden die mij interesseren werkt is vrij klein. Kijk bijvoorbeeld naar het aantal artikelen dat van ons werk gebruik maakt. Speelt de horror incerto hierin een rol?
|B. On systems
||B. Over systemen
In my 1971 paper "In
search of processes: The early history of cybernetics"
Mathematical Biosciences 11: 5-29
a conclusion was (p. 34):
"To muddle or to model, that is the question."
This sentence was used as an assignment by some authors,
and by way of an
T.F., G.J. Hademenos, W.L. Young, E. Gao,
J. Pile-Spellman and F.Vinuela. 1998
Principles and philosophy of modeling in
The FASEB Journal, 1998,
is een bijbel voor slangenhouders en -onderzoekers."
[...] is a bible for snake keepers and snake
researchers (translation by AAV).
bionieuws 24 (25-10-2014): p. 7
Links verified: 18 January 2015